Photo Timeline Of Melissa McCarthy Pinpoints When 'Ozempic Face' Rumors Began

The pressure to be thin is on full blast in Hollywood, and the use of Ozempic has been on the rise. Melissa McCarthy herself has had a stunning weight loss transformation, but it has been speculated that she had some help from Ozempic. The drug, which is typically used to treat type 2 diabetes, is not FDA-approved for weight loss. That doesn't stop people from using it for that reason, though. Many celebs have totally transformed after taking Ozempic, including Tori Spelling and Rebel Wilson. While McCarthy has neither confirmed nor denied any use of the drug, certain public appearances have left the public bewildered.

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McCarthy, who won our hearts over as Sookie in "Gilmore Girls," has been showing up to events looking slimmer than ever before. But it's not just her body that has transformed. It's also her face. Fans have said that they think the actress has 'Ozempic face' after her recent public appearances, which Cleveland Clinic defines as a gaunt, sunken, or aged appearance, caused by rapid weight loss. And these photos of McCarthy show when the 'Ozempic face' rumors began ramping up. 

Melissa McCarthy attended the Unfrosted premiere in April 2024 and her weight loss was very noticeable. It is estimated that she lost about 100 pounds. It was around this time that Barbra Streisand made a particular comment about McCarthy's weight, linking it to Ozempic. She said (in a now-deleted comment on X, via Sky News): "Give him my regards, did you take Ozempic?" Streisand later apologized for her original comment. McCarthy took the comments positively, saying in a video: "I win the day."

At the Tribeca festival in June 2024, Melissa McCarthy appeared slimmer than ever before wearing a white floral blouse and light makeup. Not only did she lose 100 pounds over recent years, but it also made a big difference in the appearance of her face. The actress' cheeks and chin looked smaller. Her eyes also looked bigger, thanks to the loss of volume around them. This was just the beginning of what turns out to be an amazing face transformation. 

When Melissa McCarthy appeared at the Museum Gala in 2025 at the American Museum of Natural History, her face was barely recognizable from her days as Sookie on "Gilmore Girls." Not only was her face slimmer, but the heavier makeup she wore added to the drastic change in her appearance. If you look closely, you can see sagging skin on her neck, which may be a sign of rapid weight loss due to a drug, such as Ozempic. 

Social media rumors about Ozempic and 'Ozempic face' began to increase after McCarthy's appearance at the Golden Globes in January 2026. One Reddit user commented: "And so what if she took ozempic, she's stunning and still looks healthy." Shortly after this appearance, McCarthy appeared on a Super Bowl ad for Elf Cosmetics. Social media users (via Daily Mail) were curious as to whether or not the actress had help with her weight loss. Some even claimed the actress had 'Ozempic face.'

Melissa McCarthy appeared at the Oscars in March 2026, fueling even more rumors about her Ozempic usage. She wore a floor-length gown covered in crystals. The dress hugged her curves to show off her new body. Her face was visibly slimmer than in previous appearances. One X user commented: "Ozempic got Melissa Mccarthy too....." McCarthy has remained silent about the rumors, which doesn't seem to be helping to put them to rest. The actress has previously shared with The Breakfast Club that she slowly lost weight (over the course of five years).

Much like Mindy Kaling, whose side-by-side photos won't help those Ozempic face rumors, Melissa McCarthy has been an advocate for body positivity for many years. She spoke to Redbook in an interview about her daughters and body image. She told the publication: "My message is that as long as everybody's healthy, enjoy and embrace whatever body type you have." She also expressed that women should stop judging one another and comparing themselves to each other. "Instead, how about if everyone wins? How intensely boring would it be if we were all the same?" McCarthy shared.