Before & After Pics Of Celebs Over 50 That Have Been Open About Ozempic & Other GLP-1 Use

Despite expert warnings that the rise of Ozempic could have lasting consequences, J.P. Morgan reported in February 2026 that the market for GLP-1s is expected to grow in the year ahead, for reasons like greater affordability and oral GLP-1 pills hitting the market. That market also includes Hollywood stars. With Hollywood's Ozempic takeover being on full display at the 2026 Grammys, it may be time to ask who in showbiz hasn't used Ozempic or any other GLP-1, as opposed to who has.

And while some celebs try to keep their transformation secrets under wraps, others are choosing to be an open book when it comes to their health and respective weight loss journeys. This has been especially true for celebs over 50, who haven't been afraid to admit that diet and exercise alone were not enough to combat the metabolic shifts and health changes that often come with aging. 

In light of all of the refreshing transparency, we're taking a closer look at the stars over 50 who have been vocal about their use of Ozempic and other GLP-1s, highlighting their striking before-and-after transformations and the stories behind their health journeys. From a legendary talk show host who believes a GLP-1 has given her a new life to an iconic actor who used Ozempic to lose the last 20 pounds on her own remarkable journey, these celebs deserve a round of applause for their candidness. 

From facelifts to her gastric bypass, Sharon Osbourne never shied away from the truth, and her experience with Ozempic was no exception. On Piers Morgan Uncensored in 2023, she said, "I didn't want to go this thin ... I lost 42 pounds now and it's just enough." In 2025, she told Daily Mail that she was struggling to gain weight after stopping the GLP-1. Compared to a 2019 Emmy Awards appearance, the reality star attended the 2026 Academy Awards Viewing Party looking strikingly gaunt.

"I can tell you what a joy it is to actually pack clothes that you know are gonna fit and you're gonna feel good in them," Oprah told CBS Sunday Morning in January 2026. Hard work and a GLP-1 have the show host feeling like she got a second chance at a more invigorating life. Side-by-side pics of Oprah from awards shows in 2014 and 2025 highlight a total transformation, with her looking more confident than ever in a ravishing custom Prada gown. 

Rosie O'Donnell, who came out much later in her career, began taking Mounjaro to control her type 2 diabetes. The comedian took to Instagram to share a photo of herself looking noticeably trimmer in May 2025, and while her caption was short, it said so much about her health journey. "I can't believe this is me now #mounjaro #weightloss #bodydysmorphia," she wrote. Comparing photos from 2019 to 2025 clearly illustrates why O'Donnell is so stunned by her own progress. 

After a 2017 type 2 diabetes diagnosis, Kathy Bates went on what would become a seven-year weight loss journey. The Oscar winner changed all of her habits and lost 80 pounds slowly. While she told People that she used Ozempic, which helped her lose another 20 pounds, it wasn't the only thing that brought her success. These photos, more than a decade apart, show just how much the actor has worked to achieve a healthier version of herself.

Joy Behar casually admitted to using a GLP-1 to lose more than 20 pounds after her co-hosts shared their success with GLP-1s on a February 2026 episode of "The View" (via PEOPLE). Known for her dry wit, Behar then said, "We all did it!" While the TV personality's transformation may not be as drastic, side-by-side pics of Behar from 2017 and 2025 showcase the obvious physical changes, but also the show host looks much happier. She's proof that it's never too late to prioritize your health. 

Although Whoopi Goldberg was always happy with who she was, she realized it was time for a change when someone mistook her for being in a fat suit while filming "Till." She knew weight loss would be the way back to her vitality after years of steroid treatments that resulted in her weighing around 300 pounds at her highest. This led her to Mounjaro, which helped her lose a substantial amount of weight. A 2026 photo shows Goldberg looking sharp and much leaner compared to a photo from 2022. 

In an emotional Instagram post in May 2025, Renee Graziano shared before-and-after weight loss pics of herself. The "Mob Wives" star wrote she had lost 52 pounds, with Mounjaro being a key factor. She struggled with negative self-talk and emotional eating, but took the time to work on those things just as much as her physical health with therapy. The reality TV star is right to be proud, as side-by-side pics from 2017 and 2025 show not just a more toned Graziano, but also a woman gleaming with confidence. 

In a January 2026 interview with Hello!, Vanessa Williams shared her secret to maintaining a youthful glow and staying in such good shape. The actor described Mounjaro as a 'game-changer' for her health after turning 60. She shared that '[her] body is not reacting the way it used to,'  and Mounjaro helped her better manage her weight throughout menopause. While the "Ugly Betty" star looked amazing in 2022, her toned arms and lean physique in 2026 prove she's mastered the art of aging gracefully. 

Postpartum weight loss isn't easy, and that's no different for celebs like Tori Spelling, which is why she opted to use a GLP-1 to aid in her weight loss. On an April 2024 episode of her podcast, "misSPELLING," she shared she tried Ozempic before finding success with Mounjaro, and side-by-side pics from 2017 and 2026 show a clear difference in Spelling's silhouette. The actor weaned off of it after losing some weight to ensure she didn't lose too much, and has clearly found a balance that works for her.  

Sunny Hostin is another host of "The View" who wanted everyone to know how she achieved her weight loss goals. On a March 2024 episode, per People, Hostin shared she'd gained 40 pounds during COVID-19, which ended up affecting her cholesterol. Mounjaro helped her lose weight and bring her cholesterol down to a healthy range again. This is evidenced when comparing photos of her from 2022 and 2024; the latter shot showcases a confident version of the talk show host, boasting the positive changes from her weight loss.