Head-Turning Transformations Of Millennial Celebs Who Used Ozempic Or Other GLP-1s

Multiple celebrities have transformed after taking Ozempic and other GLP-1s, but it's not just older stars who have been open about using the drug. Several famous millennials (those born between 1980 and 1996) have gotten candid about their experience with the medication, which is predominantly used to treat diabetes and aid weight loss. That's not too surprising considering more millennials are taking GLP-1s. A 2025 study from the Evernorth Research Institute found a 47.7% increase in millennials being prescribed the drug between 2023 and 2024. 

Equally, GLP-1 prescription company Levity discovered in 2025 that millennials had a different opinion on how tightly regulated the drug should be compared to Gen Zs (those born between 1997 and 2012). While most Gen Zs called for more regulation, most millennials wanted less. "Millennials are more likely to be prescribed a GLP-1 as compared to Gen Z; therefore, it is not surprising that millennials desire less regulation on these drugs," Richard Frank, MD, MHSA, and chief medical officer at Vida Health, explained to Newsweek. And there are plenty of millennial celebs who have had head-turning transformations on the medication.

Meghan Trainor is nearly unrecognizable after her weight loss transformation, and she hasn't gatekept how she did it. In a 2025 Instagram post, the singer told fans she used Mounjaro. "I'm so glad I did because I feel great," she wrote. That same year, the "Still Don't Care" hitmaker also opened up to Entertainment Tonight about her new look, sharing she felt like she was truly taking care of her health for the first time. "I've never felt better and I look incredible," she said.

Before and after pics of "The Secret Lives of Mormon Wives" cast's faces are wild, but Whitney Leavitt's body transformation is more dramatic. She confirmed in a 2023 YouTube video that she'd lost weight using semaglutide medication. "It's regulating my blood sugar and just, like, killing the fat and I'm just peeing it out. At least that's how I understand it," the reality star, who gave herself the shot on camera, said. However, she claimed on "It Girl" in 2025 she'd stopped taking the medication and gained the weight she lost back.

Model Remi Bader has been honest about not getting the desired effect from GLP-1s. Appearing on "Not Skinny But Not Fat" in 2023, [43:44] Bader shared she was prescribed Ozempic in 2020 for health reasons, including being pre-diabetic. "I wasn't hungry for so long, I lost some weight," she shared. The social media influencer later told Self she tried Mounjaro in late 2022, but her doctor swapped her to Ozempic in early 2023. Both made her sick, after which she stopped taking GLP-1s (but continued looking fierce on Instagram).

Ex-"The Real Housewives of New Jersey" star Lauren Manzo confirmed on Instagram in 2023 that she'd lost weight using Mounjaro. She shared before and after photos and revealed she turned to the GLP-1 medication after tying other weight loss methods, including cutting gluten out of her diet. "I'm feeling amazing and happy to feel like 'Me' again. I don't even know that girl on the left & i'm proud of how far I've come!" she wrote. And she's far from the only "Real Housewives" star who's tried Ozempic or similar.

Podcast host Bunnie Xo's GLP-1 experience exposed greater consequences than just 'Ozempic face.' She told People she started taking the shot to control her insulin, but experienced "a bout of suicidal ideation." She didn't confirm if she lost weight on the GLP-1, but previously shared during a 2024 episode of her "Dumb Blonde" podcast [5:40] she'd also tried taking tirzepatide (also known as Mounjaro). That medication made her vomit and gave her diarrhoea, exposing the bad experiences some celebs have had with GLP-1s.

Golnesa "GG" Gharachedaghi of "Shahs of Sunset" shared her Ozempic use with fans via Instagram in 2023. In a candid video, the reality star shared she'd been prescribed weight loss medication after gaining weight the year prior. "I'm not sure why so many people deny taking the shots. Y'all can judge in the comments section below," she wrote. Two months later, she revealed in another Instagram video that she was using less of the GLP-1 after losing more weight than she intended.

Podcaster Claudia Oshry was accused of falling victim to 'Ozempic face' after she opened up about using a GLP-1. She got candid about her use during a 2023 episode of "The Toast," sharing she'd lost weight but knew being on Ozempic wasn't a long-term option. "It's what's working for me now ... I don't want to be like, 'I've figured it out. I've solved the problem for life.' I have not," she said (via People).

Actor Rebel Wilson's Ozempic face transformation is wild, and she told The Sunday Times in 2024 she'd previously used Ozempic to maintain her weight loss. The "Cats" star then gave an update on her use of GLP-1s in a 2026 Instagram Stories post, suggesting she was using the medication intermittently. "But let's face it I love sweets so I need those GLP's [sic] from time to time to give a little help," she wrote (via People).

Chrissy Teigen dedicated a 2025 episode of her podcast "Self-Conscious with Chrissy Teigen" to discussing GLP-1 use. "I'm not here to judge. I've done it. Most of my friends are on it," she said on the show. The model explained she began taking Ozempic after being very open about her miscarriage, which happened in 2020. "All of a sudden, I was finally able to lose the weight that was so reminding me of the baby that I had lost," she said.