Celebs Who Bared All About Their Bad Experiences With Ozempic & Other GLP-1s

Current pop culture discourse might have you believing that Ozempic is a wonder drug. GLP-1s, colloquially referred to by the brand name "Ozempic," are a type of diabetes medication that is often prescribed off-label as a weight loss aid. Celebrities like Oprah Winfrey have been effusive in their excitement about Ozempic's possibilities. "The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for," Winfrey told People in 2023.

But there are some horror stories alongside these high-profile glow-ups, with many users reporting strong adverse reactions to GLP-1s. That's because drugs like Ozempic can have several side effects, including constipation, nausea, and even vomiting. Additionally, because medications like Ozempic can help users drop pounds rapidly, there are often visible effects of such rapid weight loss. For example, side-by-side pics of celebs who have fallen victim to Ozempic face highlight the dramatic consequences of the drug, even when it's working as intended.

Country singer Jelly Roll has dropped roughly 300 pounds in recent years, but his wife, Bunnie XO, has had a very different weight loss journey. Bunnie XO is sexy and stunning even without makeup, but she has still struggled with her body image. She began taking a GLP-1 out of a desire to lose weight, as well as manage her health, since diabetes runs in her family. But the experience quickly turned bad. "That was one of the darkest times of my life and it was scary," the podcaster told People. "I prided myself on the fact that I only had anxiety. I never had depression. So when you get slammed with suicidal ideation and visions and just, oh, it was horrific."

It wasn't Bunnie XO's first disappointing attempt at medically supported weight loss. In addition to Ozempic, she revealed that she also tried liposuction, but that it wasn't the magic bullet she hoped it would be, either. "I'm actually a huge advocate for natural bodies," she said on an episode of her Dumb Blonde podcast, explaining that she'd been disappointed by the lingering effects of liposuction on her body and the way it had impacted fat distribution.

Model Lottie Moss calls her experience with Ozempic 'the worst decision [she] ever made'. Like her sister Kate Moss, Lottie is a model, which means tremendous industry pressure to maintain her slender body type. "I think I've always really struggled with my weight since I was younger, and I think modelling didn't help, and always being around these gorgeous, tall models," she revealed on "The Price of Perfection" (via Daily Mail). But after her experience, Lottie, who obtained the Ozempic illicitly, rather than with a doctor's prescription, issued a warning about the risks of overdosing on GLP-1s.

On a 2024 episode of her podcast Dream On with Lottie Moss, she relayed her terrifying experience. "I literally had a seizure from how dehydrated I was, which honestly was the scariest thing that's ever happened to me in my life," she admitted. "My friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense." It turned out that Lottie had been taking a dose too large for her body type, which is a major risk for those taking Ozempic without medical oversight.

Remi Bader rose to prominence as a body-positive TikTok creator. Still, behind the scenes, she was struggling with self-image and striving to lose weight. "I will always believe that you could be a bigger size and be healthy and happy," she told SELF in 2025. "I was for a while, that wasn't a lie. But there was a point when it shifted, and I became really unhappy."

Starting in 2020, Bader experimented with various GLP-1 drugs, including Ozempic and Mounjaro, after her doctor told her she was pre-diabetic. However, she found the benefits negligible and the side effects debilitating. "I lost probably ten pounds, but I threw up a lot and was really sick," she explained during an appearance on the Khloe In Wonderland Podcast. "It just didn't work for me."

But even more frustrating than the side effects was the rebound effect that occurred after she went off the drug. "I went off of that and then gained even more weight," she revealed. "It was such a Band-Aid for me that when I went off it, I got ravenous." It turns out that it's quite common for people to regain weight when they stop taking GLP-1s, as the drugs are meant to be taken long-term. "This isn't a cure; this is a treatment," doctor Chika Anekwe told Scientific American.

For reality star Sharon Osbourne, GLP-1s worked a little too well, and the star dropped to under 100 pounds. The result is that she's another celeb who has fallen victim to Ozempic neck. But even after going off GLP-1s, Osbourne has struggled to regain weight. "I'm too gaunt and I can't put any weight on," she told Daily Mail. "I want to, because I feel I'm too skinny." Given that the star is over 70, such dramatic weight loss can be a serious health risk. Especially later in life, when fat and muscle are important and protective.

In sharing her negative experience with Ozempic, Osbourne expressed concern about the psychological aspects of the drug. "You can lose so much weight, and it's easy to become addicted to that, which is very dangerous," she explained. "I couldn't stop losing weight." The interaction between GLP-1 drugs and disordered eating is understudied, with some indication that they could exacerbate existing struggles. "Using Ozempic as an off-label weight loss solution can worsen restrictive eating patterns that initiate and perpetuate eating disorder progression," Samantha Brown, a social worker who specializes in eating disorders among teenagers, told Psychology Today.