Amy Schumer's 'Ozempic Face' Is Undeniable In These Side-By-Side Pics
Comedian Amy Schumer is among a growing number of Hollywood celebs who totally transformed after taking Ozempic. The star's formerly cherubic face is notably slimmer in recent photos, and the change is jaw-dropping. In the first photo below, taken in 2018, Schumer's face is fuller, while in the second photo, from 2025, the "I Feel Pretty" star's Ozempic transformation is undeniable. Her cheekbones are more prominent, and her face is no longer as full as it once was. In an Instagram caption, Schumer stated that she is "feeling strong and beautiful," and described the photos that she's shared since her weight loss as "a celebration of life and health."
Schumer has spoken frequently about her weight loss journey. She has been frank about her experience with taking Type II diabetes medication to aid that weight loss, most notably, Ozempic — which is the brand name for semaglutide — and revealed that it helped her to lose 30 pounds. More recently, she's shifted to using Mounjaro, which she finds her body responds to better. "Mounjaro's been great," she revealed in a since-deleted Instagram post [via Fox News] "I'm having a really good experience with it and I wanted to keep it real with you about that."
Amy Schumer's weight loss follows a major health diagnosis
According to Amy Schumer, she became motivated to lose weight after she was diagnosed with Cushing's syndrome. This is a disorder that occurs when the body makes too much of the hormone cortisol, and it caused Schumer's face to become notably puffy. In a since-deleted Instagram post, Schumer revealed that her weight presented major health concerns connected to the diagnosis, leading to her decision to lose weight. "I did it to survive," she wrote. "I had a disease that makes your face extremely puffy and can kill you" [via E! News].
Still, Schumer has drawn significant criticism following her weight loss, with many internet users expressing disappointment that the star has apparently turned away from the body positivity she formerly embraced. "I find it very interesting that a lot of people that used their weight/body positivity to promote themselves are now heavily on the weight loss drug train," observed one Reddit user. The use of such drugs also has doctors concerned, with experts warning that the rise of Ozempic could have lasting consequences.