How Will Izzie, Cristina, And George Return To Grey's Anatomy?

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Izzie Stevens, Cristina Yang, and George O'Malley are coming back to Grey's Anatomy in the 300th episode special! But how?!

The Grey's Anatomy 300 episode special is airing tonight, and we're just as excited as we are terrified. While 300 episodes are something Grey's fans should celebrate, we're a little nervous to see what showrunners Shonda Rhimes and Krista Vernoff have planned for the big finale for the 300th. And with Grey's Anatomy teasing the return of old ghosts like Katherine Heigl's character Izzie Stevens, T.R. Knight's character George O'Malley, and Sandra Oh's character Cristina Yang, fans are already hyped with nostalgia. But, how will Izzie, Cristina, and George return to Grey's Anatomy's 300th episode special? Will we get to see the Fab Five back in action? Will the 300th episode of Grey's be as emotionally satisfying as we hope? Hold on to your hats and grab some tequila! This one's a doozy!

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How Will Izzie Stevens, Cristina Yang, and George O'Malley Return To Grey's Anatomy's 300th Episode?

The original five interns haven't been together since the Grey's Anatomy Season 6 premiere when George (AKA 007) died in a heroic effort to save a woman from a bus. Can you believe it's been 8 seasons since? We definitely can't! And it's about damn time for an OG intern reunion! But, let's be honest, it would be pretty weird to see all of these interns reunite, considering George is dead and all. But, this is Grey's Anatomy. Anything could happen. However, we're pretty certain that the 300th episode special is not the day the reunion will take place.

Although we're getting hit by the nostalgia stick, E! News reports that actors Katherine Heigl, Sandra Oh, and T.R. Knight will not return for the 300th episode special. However, their characters will show up in spirit through a few special patients.

Get ready! Our 300th episode is happening Thursday! #Greys300 #GreysAnatomy | 📸@jessicacapshaw

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James Pickens Jr. (Chief Richard Webber) told E! News, "Episode 300 is going down kind of like memory lane. We'll see some actors who come into the hospital after a horrific accident who remind us of Izzie and George and Cristina Yang. And it's so cool how they do it. And they found three remarkable actors...When I came and I saw them, I said, 'Wow,' because they were such integral parts of the success of the show and such amazing talents in their own rights, so we miss them very much. So it will be nice for the audience to say, 'Oh wow, there they are.'"

While we're excited at even the mention of Izzie, George, and Cristina, we're pretty curious to see how these new characters will play out. Will we see characters who remind us of how Izzie, George, and Cristina once were on the show? Or perhaps their looks are enough to send Meredith Grey (Ellen Pompeo) and Alex Karev (Justin Chambers) down memory lane, giving us old flashbacks of iconic episodes? And is it possible that the 300th episode could foreshadow the return of one of these characters? Could Shonda be preparing us for a new original arc?

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Will Katherine Heigl Return To Grey's Anatomy?

While it would be interesting to see Izzie Stevens back at Grey Sloan and interacting with Alex and Jo Wilson (Camilla Luddington), we're not entirely sure that she would ever come back due to some bad blood on the set of Grey's Anatomy back in the day between Rhimes and Heigl.

In 2008, Heigl withdrew her name from consideration for an Emmy.

"I did not feel that I was given the material this season to warrant an Emmy nomination," Heigl said. "And in an effort to maintain the integrity of the academy organization, I withdrew my name from contention. In addition, I did not want to potentially take away an opportunity from an actress who was given such materials."

A few years after leaving Grey's, Heigl mentioned that she would love to return to the ABC drama in the future. But, Rhimes felt differently.

"It was really nice to hear her appreciating the show," Rhimes said. "We are on a track we have been planning, and the idea of changing that track is not something we are interested in right now."

While it has been 5 years since the subject of bringing Izzie back has been mentioned, who knows where Grey's is headed now. But, we doubt that Heigl is coming back to Grey's anytime soon.

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Will T.R. Knight Return To Grey's Anatomy?

Out of all the original interns, George's reappearance would be the hardest to explain, considering the fact that he's dead and all. While we don't expect to see him returning anytime soon (other than in flashbacks, of course), fans haven't given up hope on George's return.

A few months ago, Redditor 3bo0od07 tried to convince the Grey's Anatomy fandom that George was still alive. They argued that George was only identified through a birthmark and the fact that the injured man wrote "007" on Meredith's hand. However, the birthmark could have been anything, considering the man's body was mangled from getting hit by a bus and Miranda Bailey (Chandra Wilson) even pointed out that he could have written anything on Meredith's hand.

The Redditor even argued over why no one knew George was still alive. "George went to Iraq without saying a word," the Redditor proposed. He then decides not to tell anyone because if he died in the war, "his family and friends won't be in grief all over again."

While we would love for this fan theory to be true, we know that it's a pretty big stretch. Guess we'll just have to wait and see what Shonda has planned!

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Will Sandra Oh Return To Grey's Anatomy?

Cristina Yang is the most promising original intern to return to Grey's. And now, we know that even Oh is on board with a possible Cristina return. In fact, she even says that it "might" happen.

While promoting the 300th episode of Grey's, Kevin McKidd (Owen Hunt) said that he still keeps in touch with Oh "all the time." McKidd revealed that when his character got married to Amelia Shepherd (Caterina Scorsone), Oh got a little jealous, so McKidd told her to come back if she wanted things to change.

Her response? "Well maybe, maybe."

So, it's possible that Sandra Oh might return to Grey's Anatomy in the future! It's really a matter of when!

Are you excited for the 300th episode of Grey's Anatomy?

Grey's Anatomy Season 14 returns to ABC every Thursday at 8|7c!


Read these next:

Grey's Anatomy Season 14 Episode 7: 'Who Lives, Who Dies, Who Tells Your Story'

Grey's Anatomy 300th Episode: Air Date And Time, Spoilers, And More

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