Owen Hunt (Kevin McKidd) And Amelia Shepherd (Caterina Scorsone)
The dynamic between Owen and Amelia felt totally off from the beginning. The relationship really began when Amelia opened up to Owen about her history with drug abuse, and it wasn't long before things got intense. Not long after, the two got comfortable and decided to get married. It went pretty smoothly until Amelia found out she had a brain tumor that had to be removed. With the removal of the tumor, Amelia felt like she and Owen didn't belong together anymore. The whole situation was a total mess, and it probably will be as long as the two of them are still on the show.
George O'Malley (T.R. Knight) And Callie Torres (Sara Ramirez)
This happened so long ago, we almost forgot it ever happened. George and Callie completely jumped into their weird relationship and in season 3 got married in Vegas. The initial spark eventually faded and it was revealed that George was in love with Izzie. For this reason, the two got divorced and remained friends, how it should’ve stayed in the first place.
April Kepner (Sarah Drew) And Jackson Avery (Jesse Williams)
Let’s admit it— Jackson is totally out of April’s league and always has been. When the two joined the show during the merger with Mercy West, we would’ve never imagined in a million years they would become a couple. The marriage didn’t happen until Jackson stood up during April’s wedding with another man and objected it. So clearly, the relationship was a mess from the start.
Alex Karev (Justin Chambers) And Rebecca/Ava
In Alex's defense, he didn't know Rebecca was a complete whackjob when he decided to date a patient. It was kinda cute how he saved her life and all, but it should’ve been left at that. Rebecca wasn’t taking her recovery well and Alex couldn’t be there for her as often as he needed to be. I mean, she should’ve known she couldnt expect that much from a surgeon.
Teddy Altman (Kim Raver) and Henry Burton (Scott Foley)
This was a joke of a relationship, and we only feel bad saying so because Henry died. The grounds of their marriage wasn’t love at all, but insurance purposes. Teddy suggested that the two get legally married so he could receive the proper treatment he needed for his condition. As time passed, their forced relationship became a little too real. It ended abruptly when Henry died while Cristina Yang (Sandra Oh) was operating on him, unaware he was the husband of her mentor.